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Contraindicated (1)pentobarbital will decrease the level or result of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or impact of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will decrease the extent or impact of ethotoin